Effect of Short Sleep Duration on the Risk of Cardiovascular Diseases: A Meta-Analysis

Authors

  • Anas Rahmad Hidayat Health Polytechnic of Permata Indonesia, Yogyakarta, Indonesia
  • Harpeni Siswatibudi Health Polytechnic of Permata Indonesia, Yogyakarta, Indonesia
  • R. Haryo Nugroho Purwokusumo Health Polytechnic of Permata Indonesia, Yogyakarta, Indonesia

DOI:

https://doi.org/10.26911/jepublichealth.2025.10.05.11

Abstract

Background: Understanding the impact of short sleep duration on cardiovascular disease incidence is crucial for comprehending its potential health implications. This study aimed to analyze and estimate the magnitude of the effect of short sleep duration on the risk of cardiovascular disease incidence based on similar previous primary studies.
Subjects and Method: This research is a systematic review and meta-analysis conducted by following the PRISMA flow diagram and PICO model. Population: general population without prior cardiovascular diseases, Intervention: short sleep duration, Comparison: adequate sleep duration, and Outcome: the Incidence of cardiovascular diseases. The process of searching for articles through Google Scholar, ProQuest, and PubMed journal databases by selecting articles published from 2010 to 2024. The keywords used include: "Cardiovascular Diseases," AND "Incidence," AND "Sleep Duration," AND "cohort Studies. The inclusion criteria were full paper articles, open access with a cohort study design, and articles in English. Data were analyzed using RevMan 5.3.
Results: A total of 9 cohort studies involving 564,287 respondents from Africa, Europe, and Asia were selected for a systematic review and meta-analysis. The results of the meta-analysis showed that people with short sleep duration had a 1.20 times risk of experiencing cardiovascular disease compared to people with adequate sleep duration (aHR = 1.20; 95% Cl = 1.14 to 1.25; p<0.001). This meta-analysis has heterogeneity I2= 39%, so it uses a fixed effect model.
Conclusion: Insufficient sleep duration could elevate the likelihood of cardiovascular disease occurrence.

Keywords:

Cardiovascular disease, incidence, short sleep, sleep duration

Correspondence

Anas Rahmad Hidayat. Health Polytechnic of Permata Indonesia. Jl. Pandean II No.21a, Candok, Condongcatur, Kec. Depok, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55281, Indo­nesia. Email: anasrh@permataindonesia.ac.id.  Mobile: 081226016016.

References

Ai S, Zhang J, Zhao G, Wang N, Li G, So H.C, Liu Y, et al. (2021). Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank. Eur Heart J. 42(34): 3349–3357. doi: 10.1093/eurheartj/ehab170.

Amagai Y, Ishikawa S, Gotoh T, Kayaba K, Nakamura Y, Kajii E (2010). Sleep Duration and Incidence of Cardio-vascular Events in a Japanese Population: The Jichi Medical School Cohort Study. J Epidemiol. 20(2): 106–110. doi: 10.2188/jea.JE20090053.

Beaman A, Bhide MC, McHill AW, Thosar SS (2021). Biological pathways underlying the association between habitual long sleep and elevated cardiovascular risk in adults. Sleep Med. 78: 135–140. doi: 10.1016/j.sleep.2020.12.011.

Canivet C, Nilsson PM, Lindeberg SI, Karasek R, Östergren P-O (2014). Insomnia increases risk for cardiovascular events in women and in men with low socioeconomic status: a longitudinal, register-based study. J Psychosom Res. 76(4):292–299. doi: 10.1016/j.jpsychores.2014.02.001.

Cappuccio FP, Cooper D, D’Elia L, Strazzullo P, Miller MA (2011). Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. 32(12): 1484–1492. doi: 10.1093/eurheartj/ehr007.

Dashti HS, Daghlas I, Lane JM, Huang Y, Udler MS, Wang H, Ollila HM, et al. (2021). Genetic determinants of day-time napping and effects on cardio-metabolic health. Nat Commun. 12(1): 900. doi: 10.1038/s41467-020-20585-3.

Ferrie JE, Kumari M, Salo P, Singh-Manoux A, Kivimäki M (2011). Sleep epidemiology a rapidly growing field. Inter J Epidemiol. 40(6):1431–1437. doi: 10.1093/ije/dyr203.

Genderson MR, Rana BK, Panizzon MS, Grant MD, Toomey R, Jacobson KC, Xian H, et al. (2013). Genetic and environmental influences on sleep quality in middle-aged men: a twin study. J Sleep Res. 22(5), 519–526. doi: 10.1111/jsr.12048.

Gianfagna F, Veronesi G, Bertù L, Cesana G, Grassi G, Stranges S, Callegari C, et al. (2016). Influence of sleep disturbances on age at onset and long-term incidence of major cardiovascular events: the MONICA-Brianza and PAMELA cohort studies. Sleep Med. 21: 126–132. doi: 10.1016/j.sleep.2016.01.007.

Global Burden of Disease Study 2017 (2018). Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392(10159). 1736–1788. doi: 10.1016/S0140-6736(18)32203-7.

Hamazaki Y, Morikawa Y, Nakamura K, Sakurai M, Miura K, Ishizaki M, Kido T, et al. (2011). The effects of sleep duration on the incidence of cardiovascular events among middle-aged male workers in Japan. Scand J Work Environ Health. 37(5): 411–417. doi: 10.5271/sjweh.3168.

Hoevenaar-Blom MP, Spijkerman AMW, Kromhout D, van den Berg JF, Verschuren W MM. (2011). Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study. Sleep. 34(11):1487–1492. doi: 10.5665/sleep.1382.

Huang YM, Xia W, Ge YJ, Hou JH, Tan L, Xu W, Tan CC. (2022). Sleep duration and risk of cardio-cerebrovascular disease: A dose-response meta-analysis of cohort studies comprising 3.8 million participants. Front Cardiovasc Med. 9(9): 1–11. doi: 10.3389/fcvm.2022.907990.

Itani O, Jike M, Watanabe N, Kaneita Y. (2017). Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression. Sleep Med. 32:246–256. doi: 10.1016/j.sleep.2016.08.006.

Kyu HH, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, et al. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 392(10159): 1859–1922. doi: 10.1016/S0140-6736(18)32335-3.

Li M, Zhang XW, Hou WS, Tang ZY (2014). Insomnia and risk of cardiovascular disease: a meta-analysis of cohort studies. Inter J Cardiol. 176 (3): 1044–1047. doi: 10.1016/j.ijcard.2014.07.284.

Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. (2013). Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 177(9): 1006–1014. doi: 10.1093/aje/kws342.

Riggs DW, Yeager RA, Bhatnagar A. (2018). Defining the Human Environment: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease. Circulation Res. 122(9): 1259–1275. doi: 10.1161/CIRCRESAHA.117.311230.

Song C, Chang Z, Magnusson PKE, Ingelsson E, Pedersen NL (2014). Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors. J Intern Med. 275(6): 631–639. doi: 10.1111/joim.12177.

St-Onge MP, Grandner MA, Brown D, Conroy MB, Jean-Louis G, Coons M, Bhatt DL (2016). Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association. Circulation. 134(18) :367–386. doi: 10.1161/CIR.000000-0000000444.

Tao F, Cao Z, Jiang Y, Fan N, Xu F, Yang H, Li S, et al. (2021). Associations of sleep duration and quality with incident cardiovascular disease, cancer, and mortality: a prospective cohort study of 407,500 UK biobank participants. Sleep Med. 81:401–409. doi: 10.1016/j.sleep.2021.03.015.

Wang C, Bangdiwala SI, Rangarajan S, Lear SA, AlHabib KF, Mohan V, Teo K, et al. (2019). Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116,632 people from 21 countries. Eur Heart J. 40(20): 1620–1629. doi: 10.1093/eurheartj/ehy695.

Wang Y-H, Wang J, Chen S-H, Li J-Q, Lu Q-D, Vitiello MV, Wang F, et al. (2020). Association of Longitudinal Patterns of Habitual Sleep Duration With Risk of Cardiovascular Events and All-cause Mortality. JAMA Net Open. 3(5): e205246. doi: 10.1001/jamanetworkopen.2020.5246.

Wang Z, Yang W, Li X, Qi X, Pan KY, Xu W (2022). Association of Sleep Duration, Napping, and Sleep Patterns With Risk of Cardiovascular Diseases: A Nationwide Twin Study. J Am Heart Assoc. 11(15): e025969. doi: 10.1161/JAHA.122.025969

Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, et al. (2015). Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion. JCSM; J Clin Sleep Med. 11(8): 931–952. doi: 10.5664/jcsm.4950.

Westerlund A, Bellocco R, Sundström J, Adami HO, Åkerstedt T, Trolle Lagerros Y (2013). Sleep characteristics and cardiovascular events in a large Swedish cohort. Eur J Epidemiol. 28(6): 463–473. doi: 10.1007/s10654-013-9802-2.

Yin J, Jin X, Shan Z, Li S, Huang H, Li P, Peng X, et al. (2017). Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. J Am Heart Assoc. 6(9). doi: 10.1161/JAHA.117.005947.

Zheng B, Yu C, Lv J, Guo Y, Bian Z, Zhou M, Yang L, et al. (2019). Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: A 10-year cohort. Neurology. 93(23): 2110–2120. doi: 10.1212/WNL.0000000000008581.

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Published
2025-01-16

Issue
Vol. 10 No. 1 (2025)

Section
flow-chart-line Articles

How to Cite
Hidayat, A. R., Siswatibudi, H., & Purwokusumo, R. H. N. (2025). Effect of Short Sleep Duration on the Risk of Cardiovascular Diseases: A Meta-Analysis. Journal of Epidemiology and Public Health, 10(1), 115–125. https://doi.org/10.26911/jepublichealth.2025.10.05.11

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