Correlations between History of Contact with Infected Person and Measles Vaccination Status on the Risk of Measles Incidence in Children: Meta-Analysis


  • Ervia Fahma Dhony Master’s Program in Public Health, Universitas Sebelas Maret
  • Bhisma Murti Master’s Program in Public Health, Universitas Sebelas Maret
  • Hanung Prasetya Study Program of Acupuncture, Health Polytechnics, Ministry of Health Surakarta



Background: Measles is a disease that can be prevented by immunization (VPD), which is highly contagious and often causes widespread outbreaks and can cause lifelong complications and death. Some evidence suggests that the risk of measles is due to contact history and vaccine status. This study aims to estimate the magnitude of the relationship between contact history and vaccine status with the incidence of measles in children, through a meta-analysis of primary studies conducted by previous authors.
Subjects and Method: This research is a systematic review and meta-analysis with PICO as follows, Population: children. Intervention: contact history, vaccine status. Comparison: no contact history, no vaccine. Outcome: measles. The articles used in this research were obtained from three databases, namely PubMed, Google Scholar, and Science Direct, using the keys "History contact" AND "Vaccine" OR "Vaccinated" OR "Immunization" AND "Measles" AND "Children. The included articles were full-text with a case-control study design from 2012 to 2023 and reported the adjusted Odds Ratio (aOR) in multivariate analysis. Article selection was carried out using the PRISMA flow diagram. Articles were analyzed using the Review Manager 5.3 application.
Results: A total of 8 case-control studies involving the African continent and the Asian continent were selected for meta-analysis. Children with a history of contact have an increased risk of developing measles 4.38 times compared with children without a history of contact, and this relationship is statistically significant (aOR=4.38; 95% CI=1.36 to 14.09; p= 0.010). Children who had been given the measles vaccine had a reduced risk of getting measles 0.30 times compared to children who had not been given the measles vaccine, and this result was statistically significant (aOR= 0.30; 95% CI= 0.22 to 0.40; p< 0.001).
Conclusion: Contact history statistically significantly increases the risk of getting measles in children, vaccine statistically significantly reduces the risk of getting measles in children.

Keywords: Contact history, vaccine status, measles, children.


Anggreani GN, Prasetya H, Murti B (2023). Application of Theory of Planned Behavior on Vaccine Uptake in Palu, Central Sulawesi, Indonesia. J health promotion behavior. 8(2): 116–126. doi: 10.26911/thejhpb.2023.08.02.06.

Antona D, Lévy BD, Baudon C. Freymuth F, Lamy M, Maine C, Floret D, Du IP (2013). Measles Elimination Efforts and 2008-2011 Outbreak, France. Rom J Infect. 16(1), 16–24. doi: 10.3201/eid1903.121360.

Arianto M, Setiawati M, Adi MS, Hadisaputro S, Budhi K (2018). Beberapa Faktor Risiko Kejadian Campak Pada Balita di Kabupaten Sarolangun (Several Risk Factors for Measles in Toddlers in Sarolangun Regency). JEKK. 3(1), 41. doi: 10.14710/jekk.v3i1.3127

Babalola OJ, Ibrahim IN, Kusfa IU, Gidado S, Nguku P, Olayinka A, Abubakar A (2019). Measles Outbreak Investigation In An Urban Slum Of Kaduna Metropolis, Kaduna State, Nigeria, March 2015. Pan Afr Med J. 32: 1–10. doi: 10.11604/pamj.2019.32.150.15764

Bose AS, Rai P, Gupta BP, Pradhan R, Lacoul M, Shakya S, et al (2022). Nepal Measles Outbreak Response Immunization during COVID-19: A Risk-Based Intervention Strategy. Vaccine. 40(20): 2884–2893.

Bukuno S, Asholie A, Girma Z, Haji Y. (2023). Measles Outbreak Investigation in Garda Marta District, Southwestern Ethiopia, 2022: Community-Based Case-Control Study. Infect. Drug Resist. 16(4): 2681–2694. doi: 10.2147/IDR.S405802

CDC (2019). Measles (rubeola): measles elimination. Atlanta, GA: US Department of Health and Human Services. Central of Disease Control.

CDC (2022). Global Measles And Rubella Updates. Central of Disease Control.

CDC (2023). Measles Cases and Outbreaks. Central of Disease Control.

Dinkes Jawa tengah. (2021). Buku Profil Kesehatan Jawa Tengah Tahun 2021. Dinas Kesehatan Jawa Tengah.

Dunn JJ, Baldanti F, Puchhammer E, Panning M, Perez O, Harvala H (2020). Measles is a back-consider option for laboratory diagnosis. J Clin Virol. 128: 104430. doi: 10.1016/j.jcv.2020.104430

Girmay A, Dadi AF (2019). Being unvaccinated and having a contact history increased the risk of measles infection during an outbreak: BMC Infect. Dis. 19(1): 1–6. doi: 10.1186/s1-2879-019-3973-8.

Henszel L, Kanitz EE, Grisold A, Holzmann H, Aberle SW, Schmid D (2020). Vaccination status and attitude among measles cluster cases in Austria, 2019. Int J Environ Res. 17(24): 1–10. doi: 10.3390/ijerph17249377.

Ichimura Y, Yamauchi M, Yoshida N, Miyano S, Komada K, Thandar MM (2022). Effectiveness of immunization activities on measles and rubella immunity among individuals in East Sepik, Papua New Guinea: A cross-sectional study. IJID Reg. 3:84-8. Epub 20220303. doi: 10.1016/j.ijregi.2022.03.001.

Kalil FS, Gemeda DH, Bedaso MH, Wario SK (2020). Measles outbreak investigation in Ginnir District of bale zone, oromia region, Southeast Ethiopia, May 2019. Pan Afr Med. 36: 1–12. doi: 10.11604/pamj.2020.36.20.21169

Kidan F, Getachew D, Mekonnen B, Ham-meso WW (2021). Risk factors of measles outbreak among students of mizantepi university, tepi campus, Southwest Ethiopia. Infect Drug Resist. 14: 963–970. doi: 10.2147/IDR.S29-6928

Ludlow M, McQuaid S, Milner D, Swart RLD, Duprex WP (2015). Pathological consequences of systemic measles virus infection. In J Exp Pathol. 235(2): 253–265. doi: 10.1002/path.4457.

Mat DM, Yaacob NA, Ibrahim MI, Wan WA (2022). Five-Year Trend of Measles and Its Associated Factors in Pahang, Malaysia: A Population-Based Study. Environ. Res, 19(13). doi: 10.3390/ijer-ph19138017

Mebrate M, Hailu C, Alemu S (2023). Measles outbreak investigation in Kasoshekumer kebele, Sinana district, South-Eastern Oromia, Ethiopia: A case-control study. SAGE Open Med. 11. doi: 10.1177/20503121231169182

Morgan E, Halliday SR, Campbell GR, Card-well CR, Patterson CC (2016). Vaccinations and Childhood Type 1 Diabetes Mellitus: A Meta-Analysis of Observational Studies. Diabetologia, 59(2): 237–243. doi: 10.1007/s00125-015-3800-8.

Munawaroh SM, Murti B (2023). Penilaian Kritis (Critical Appraisal) Studi Case Control For Meta-Analysis Research (Critical Appraisal of Case-Control Studies for Meta-Analysis Research).

Nassar H, Abdullah M, Amad A, Qasim M (2021). Risk factors for measles outbreak in Ataq and Habban districts, Shabwah. BMC Infec Dis. doi: 10.1186/s12879-021-06207-3.

Oktaviasari KE (2018). Relationship of Measles Immunization with Measles in East Java. JBE. 6(2), 166. doi: 10.20473/jbe.v6i22018.166-173

Patel M, Lee AD, Clemmons NS, Redd SB, Poser S, Blog D, Zucker JR, et al. (2020). National update on measles cases and outbreaks — United States, January 1 to October 1, 2019. Am J Transplant 20(1): 311–314. Doi: 10.1111/ajt.15728.

Peart AN (2022). Updates in the Epidemiology, Approaches to Vaccine Coverage and Current Outbreaks of Measles. Infect Dis Clin North Am. 36(1): 39–48. doi: 10.1016/j.idc.2021.11.010.

Pomerai KW, Mudyiradima RF, Gombe NT (2012). Measles outbreak investigation in Zaka, Masvingo Province, Zimbabwe, 2010. BMC Res. 5: 2–7. Doi: 10.1186/1756-0500-5-687.

Rivadeneira MF, Bassanesi SL, Fuchs SC (2018). Role of health determinants in a measles outbreak in Ecuador: A case-control study with aggregated data. BMC Public Health. 18(1): 1–8. doi: 10.1186/s12889-018-5163-9.

Rosadi W, Sulaeman ES, Prasetya H (2019). Multilevel Analysis on Factors Affecting Measles-Rubella Immunization Uptake among Toddlers in Pekanbaru, Indonesia. J Maternal and Child Health. 4(6): 448–460. doi: 10.26911/thejmch.2019.04.06.06

Sitepu FY, Depari E, Mudatsir M, Harapan H (2020). Being unvaccinated and contact with measles cases as the risk factors for measles outbreak, North Sumatra, Indonesia. Clin Epidemiol Glob Health. 8(1):239–243. doi: 10.1016/j.cegh.2019.08.006

Tang ZZ, Xie YH, Jiraphongsa C, Liu X H, Li Z Y, Chongsuvivatwong V. (2016). Risk factors for measles in children younger than age 8 months: A case-control study during an outbreak in Guangxi, China, 2013. Am J Infect Control. 44(4): e51–e58. doi:10.1016/j.ajic.2015.11.005.

Tsegaye G, Gezahegn Y, Tesfaye A, Mulatu G, Bulcha GG, Berhanu N (2022). Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021. Infect. Drug Resist. 15: 669–683. doi: 10.2147/IDR.S343270.

Vemula VN, Li L, Thoon KC, Chong CY, Tee NWS, Maiwald M, Tan NWH (2016). Risk factors and clinical profile of measles infection in children in Singapore. Infect Dis Health 21(4). doi: 10.1016/j.idh.2016.11.004.

WHO (2014). WHO Measles Fact Sheet. WHO Measles Fact Sheet, November 2014–2016. World Health Organization.

WHO (2020). Measles occupied Palestinian territory. World Health Organization.

WHO (2023a). Measles. World Health Organization.

WHO (2023b). Measles Indonesia. World Health Organization.

Xiang Z, Ningjing Z, Xiaoshu Z, Lixin H, Qiru S, Haijun W, Kongyan M, et al. (2015). Investigation of a measles outbreak in China to identify gaps in vaccination coverage, routes of transmission, and interventions. PLoS ONE. 10(7):1–11. doi: 10.1371/journal.pone.0133983.




How to Cite

Dhony, E. F., Murti, B., & Prasetya, H. (2024). Correlations between History of Contact with Infected Person and Measles Vaccination Status on the Risk of Measles Incidence in Children: Meta-Analysis . Journal of Epidemiology and Public Health, 9(2), 156–169.




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