Risk Factors of Pulmonary Tuberculosis in Type 2 Diabetes Mellitus in Yogyakarta
DOI:
https://doi.org/10.26911/jepublichealth.2024.09.02.06Abstract
Background: The prevalence of pulmonary tuberculosis (TB) increases along with the increasing prevalence of Type 2 Diabetes Mellitus (T2DM) patients. The frequency of TB in type 2 DM patients (10 to 15%) and the prevalence of this infectious disease is 2 to 5 times higher in DM patients compared to non-diabetics. This study aimed to analyze the risk factors for pulmonary TB in T2DM patients in Yogyakarta.
Subjects and Method: This study uses a case-control study design conducted at RESPIRA Lung Hospital Yogyakarta from January 16 to February 20, 2023. The number of samples was 52 people with a total of 26 people in the case and control groups. Samples were taken by consecutive sampling technique. The independent variables were age, gender, employment, education, BMI, smoking status, clinical symptoms, family history of TB, previous history of TB, and income level). The dependent variable is the incidence of TB in DM patients. Control groups are respondents without a diagnosis of DM and TB patients. Conversely, the cases are personal with diagnosis TB and DM patient Data were collected using a questionnaire. Data analysis was carried out descriptively, bivariate with Chi-square, and multivariate with multiple logistic regression.
Results: The demonstrated research that the risk factors that influence the incidence of TB in T2DM patients are gender (aOR = 9.60; 95% CI: 0.14 to 55.96; p=0.012), Age (aOR=0.24; 95% CI: 0.07 to 0.76; p=0.015).
Conclusion: The female sex has a 9.60 times higher risk of experiencing TB compared to men in T2DM patients.
Keywords:
diabetes mellitus, pulmonary tuberculosis, risk factorsReferences
Alisjahbana B, Hadisoemarto P, Lestari BW (2020) Diagnosis dan Pengelolaan Tuberkulosis. Bandung: Unpad Press.
ADA (2018) Good to Know: Factors Affecting Blood Glucose, American Diabetes Association. doi: 10.2337/cd18-0012.
Anwar MC, Budiono I, Nisa AA (2022) Validity of Pulmonary Tuberculosis Control Success Index (TBCSI) Instrument. Unnes J Public Health. 11(1): 82–89.
Baghaei P, Marjani M, Javanmard P, Tabarsi P, Masjedi MR (2013). Diabetes Mellitus and tuberculosis facts and controversies. J Diabetes Metab Disord. 12(1): 1–8. doi:10.1186/2251-6581-12-58.
Einarson TR, Acs A, Ludwig C, Panton UH (2018). Prevalence of cardiovascular disease in type 2 diabetes: A systematic literature review of scientific evidence from across the world in 2007-2017. Cardiovasc Diabetol. 17(1): 1–19. doi:10.1186/s12933-018-0728-6.
Girardi E, Schepisi MS, Goletti D, Bates M, Mwaba P, Yeboah-Manu D, Ntoumi F, et al. (2017). The global dynamics of diabetes and tuberculosis: the impact of migration and policy implications. Int J Infect Dis. 56: 45–53. doi: 10.1016/j.ijid.2017.01.018.
Gotera W, Nugraha IBA, Yustin WEF (2021). Diabetes Melitus sebagai Faktor Risiko Tuberkulosis. J Kedokteran Meditek. 27(3): 273–281.
IDF (2021). IDF Diabetes Atlas 2021. International diabetes federation. doi: 10.1242/jeb.64.3.665.
Kemenkes RI (2018) Buku Pedoman Penyakit Terkait Rokok. Kementerian Kesehatan Republik Indonesia.
Khalil NH, Ramadan RA (2016). Study of risk factors for pulmonary tuberculosis among diabetes mellitus patients. Egypt J Chest Dis Tuberc. 65(4): 817–823. doi: 10.1016/j.ejcdt.2016.05.009.
Gautam S, Shrestha N, Mahato S, Nguyen TPA, Mishra SR, Berg-Beckhoff G (2021). Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: a systematic review and meta-analysis. Sci Rep. 11(1):2113.
Lawrence H, Moore T (2021). Crash Course Respiratory Medicine. Singapore: Elsevier.
Lusiani E (2019a). Faktor Risiko Terjadinya Manifestasi TB Paru Pada Penderita DM Tipe 2 dengan Tes Mantoux Positif. J Keperawatan Muhammadiyah.
Lusiani E (2019b). Faktor Risiko Terjadinya Manifestasi TB Paru Pada Penderita DM Tipe 2 Dengan Tes Mantoux Positif. J Keperawatan Muhammadiyah.
Mihardja L, Lolong DB, Ghani L (2015). Prevalensi Diabetes Melitus pada Tuberkulosis dan Masalah Terapi. J Ekologi Kesehatan. 14(4): 350–358.
Nasution F, Andilala, Siregar AA (2021). Risk Factors for The Event of Diabetes Mellitus. J Ilmu Kesehatan. 9(2): 94–102.
Ridwan M (2020). Mengenal & Menjaga Kesehatan Pernafasan. Yogyakarta: Hikam Pustaka.
Dewi DPR, Putra IWGEA, Sawitri AAS, Duarsa DP (2017). Risk factors of pulmonary tuberculosis among diabetes mellitus patients in Denpasar City. Public health prev. med. 5(1): 24. doi:10.24843/phpma.2017.v05.i01.p04.
Rohman H (2018). Kasus Tuberkulosis Dengan Riwayat Diabettes Mellitus Di Wilayah Prevalensi Tinggi Diabettes Mellitus. JMIKI. 6(2): 149. doi: 10.33560/.v6i2.201.
Savitri AR (2021). Karakteristik Penderita Tuberkulosis Paru Dengan Diabetes Melitus Di Kabupaten Badung Tahun 2017-2018. E-Jurnal Medika Udayana. 10(1): 60–64.
Somantri I (2007). Asuhan Keperawatan Pada Pasien dengan Gangguan Sistem Pernapasan. Jakarta: Salemba Medika.
Suprapto, Hariati, Ningsih OS, Solehudin, Faizah A, Achmad VS, Sugiharno RT, et al. (2022) Keperawatan Medikal Bedah. Padang: PT Global Eksekutif Teknologi.
Suryo J. (2010) HERBAL: Penyembuh Gangguan Sistem Pernapasan. Yogyakarta: B First.
WHO (2020a). Global Strategy for the Prevention and Control of NCDs. World Health Organization.
WHO (2020b) Global Tuberculosis Report 2019. World Health Organization.
Workneh MH, Bjune GA, Yimer SA (2017). Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity : A systematic review. PLoS One, 12(4): 1–25.
Wulandari DR, Sugiri YJ (2013). Diabetes Melitus dan Permasalahannya pada Infeksi Tuberkulosis. J Respir Indo. 33(2): 126–134.
Yanti Z (2017). Pengaruh Diabetes Melitus Terhadap Keberhasilan. J Berkala Epidemiologi. 5: 163–173. doi: 10.20473/jbe.v5i2.2017.163-173.
Yosephine MK, Hardy FR, Wenny DM, Nurrizka RH, Pulungan RM (2021). Faktor yang Memengaruhi Kejadian Tuberkulosis Paru pada Penderita Diabetes Mellitus di Rumah Sakit X. J Kesehatan. 12(3): 344. doi: 10.26630/jk.v12i3.2542.
Zheng H, Sun W, Zhang Q, Zhang Y, Ji L, Liu X, Zhu X, et al. (2021). Proinflammatory cytokines predict the incidence of diabetic peripheral neuropathy over 5 years in Chinese type 2 diabetes patients: A prospective cohort study. EClinicalMedicine. doi: 10.1016/j.eclinm.2020.100649
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Published
2024-04-16
Issue
Vol. 9 No. 2 (2024)
Section
Articles
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