The Effect of Maternal Anemia on Low Birth Weight: Meta Analysis

Authors

  • Elsa Tursina Study Program Acupunctur, Diploma IV, Health Polytechnics, Ministry of Health Surakarta
  • Fahmi Adhimukti Study Program of Midwifery, Diploma IV, Health Polytechnics, Ministry of Health Yogyakarta

DOI:

https://doi.org/10.26911/jepublichealth.2022.07.02.03

Abstract

Background: Low birth weight is still a global public health problem that is associated with a number of risks. One of the factors that influence the occurrence of LBW is anemia. This study was aimed to estimate the risk of anemia in pregnant women to the incidence of LBW in several countries.
Subjects and Method: This study is a meta-analysis with PICO, Population: pregnant women. Intervention: maternal anemia. Comparison: no maternal anemia. Result: LBW. The articles used in this study were obtained from three databases namely Google Scholar, Pubmed, and Science Direct with a cohort study design from 2015 to 2022 that reported Adjusted Odds Odds Ratio in its multivariate analysis. The selection of articles was carried out using the PRISMA flow chart. Analysis of articles using the Review Manager 5.3 application.
Results: A total of 9 cohort studies involving 75,807 pregnant women from Taiwan, China, Japan, India, Bangladesh, Iran, and Colombia were selected for systematic review and meta-analysis. The data collected showed that pregnant women who were anemic during pregnancy had a 1.3 times higher risk of giving birth to babies with low birth weight than non-anemic mothers, but this result was not statistically significant (aOR= 1.30; 95% CI= 0.89 to 1.88; p= 0.170). With an intuitive index of 84%, so the effect between the studies is heterogeneous.
Conclusion: Mothers who experience anemia during pregnancy have a risk of giving birth to babies with low birth weight.

Keywords: anemia, pregnancy, low birth weight

Correspondence:
Fahmi Adhimukti. Study Program of Midwifery, Diploma IV, Health Polytechnics, Ministry of Health Surakarta. Jl. Tata Bumi 3, Sleman, Yogyakarta, Indonesia. Email: fahmiadhimukti13@gmail.com. Mobile: 085743155133.

References

Angraini D, Efriyan I, Reni Z, Sofyan M (2020). Pengaruh status gizi terhadap kejadian anemia pada ibu hamil di daerah endemis malaria Kabupaten Pesawaran (The effect of nutriational status on the incidence of anemia in pregnant women in malaria endemic areas, Pesawaran Regency). J Kesehat Unila. 4: 107–111.

Anwar R, Razzaq K, Noor N (2019). Impact of maternal anemia on perinatal outcome. Pak Armed Forces Med J. 69(2): 397–402.

Bakacak M, Avci F, Ercan O, Köstü B, Serin S, Kiran G, et al. (2015). The effect of maternal hemoglobin concentration on fetal birth weight according to trimesters. J Matern Fetal Neonatal Med. 28(17): 2106–2110. doi: 10.3109/14767058.2014.979149.

Bhaskar RK, Deo KK, Neupane U, Chaud-hary B, Yadav BK, Pokharel HP, Po-Khare PK (2015). A case-control study on risk factors associated with low birth weight babies in Eastern Nepal. Int J Pediatr. 1–7. doi: 10.1155/2015/807373.

Biswas P, Samsuzzaman M, Chakraborty A, Das DK (2019). Maternal anemia and low birth weight in a community development block of Purba Bardha-man, West Bengal: a retrospective cohort analysis. Int J Community Med Public Health. 6(12): 5250. doi: 10.18203/23946040.ijcmph20195480.

Carpenter RM, Billah SM, Lyons GR, Siraj MS, Rahman QS, Thorsten V, Mc-Clure EM, et al. (2021). U-shaped association between maternal hemoglobin and low birth weight in Rural Bangladesh. Am J Trop Med Hyg. 106(2): 424–431. doi: 10.4269/ajtmh.210268.

Chu FC, Shaw SW, Lo LM, Hsieh TT, Hung TH (2020). Association between maternal anemia at admission for delivery and adverse perinatal outcomes. J Chin Med Assoc. 83(4): 400–405. doi: 10.1097/jcma.0000000000000215.

Feresu SA, Harlow SD, Woelk GB (2015). Risk factors for low birthweight in Zimbabwean women: A secondary data analysis. PLoS ONE. 10(6), 1–17. doi: 10.1371/journal.pone.0129705.

Heydarpour F, Soltani M, Najafi F, Ta-database HR, Etemad K, Hajipour M, Babanejad M, et al. (2019). Maternal anemia in various trimesters and related pregnancy outcomes: Results from a large cohort study in Iran. Iran J Pediatr. 29(1). doi: 10.5812/ijp.69741.

Jwa SC, Fujiwara T, Yamanobe Y, Kozuka K, Sago H (2015). Changes in maternal hemoglobin during pregnancy and birth outcomes. BMC Pregnancy and Childbirth. 15(1). doi: 10.1186/s12884-015-0516-1.

Kadir S (2019). Faktor penyebab anemia defisiensi besi pada ibu hamil di wi-layah kerja Puskesmas Bongo Nol Kabupaten Boalemo (Factors Causing Iron Deficiency Anemia in Pregnant Women in the Working Area of Bongo Nol Health Center, Boalemo Re-gency). Jambura J of Health Sci Res. 1(2): 54–63. doi: 10.35971/jjhsr.v1i2.2396.

Kemenkes RI (2018). Hasil riset kesehatan dasar tahun 2018 (The results of basic health research in 2018). Badan Penelitian dan Pengembangan Dasar. RI. 53(9): 1689–1699.

Masukume G, Khashan AS, Kenny LC, Baker, PN, Nelson G (2015). Risk factors and birth outcomes of anemia in early pregnancy in a nulliparous cohort. PLoS ONE. 10(4): 1–15. doi: 10.1371/journal.pone.0122729.

Mitao M, Philemon R, Obure J, Mmbaga B T, Msuya S, Mahande MJ (2016). Risk factors and adverse perinatal outcome associated with low birth weight in Northern Tanzania: A registry-based retrospective cohort study. Asian Pac J Reprod. 5(1): 75–79. doi: 10.1016/j.apjr.2015.12.014.

Moghaddam TF, Barjasteh S (2015). Maternal hemoglobin levels during pregnancy and their association with birth weight of neonates. Iran J of Pediatr Hematol and Oncol. 5(4): 211–217. http://www.ncbi.nlm.nih.gov/pubmed/26985354

Nair M, Choudhury MK, Choudhury SS, Kakoty SD, Sarma UC, Webster P, Knight M (2016). Association between maternal anemia and pregnancy outcomes: A cohort study in Assam, India. BMJ Global Health. 1(1): 1–9. doi: 10.1136/bmjgh-2015-000026.

Nur AF (2018). Anemia and low birth weight in Hospital of Anutapura Palu. Ghidza: Jurnal Gizi Dan Kese-hatan. 2(2): 63–66.

Puerto A, Trojan A, Alvis-Zakzuk NR, Ló-pez-Saleme R, Edna-Estrada F, Alva-rez A, Alvis-Guzman N, Zakzuk J (2021). Iron status in late pregnancy is inversely associated with birth weight in Colombia. J Public Health Nutr. 24(15): 5090–5100. doi: 10.1017/s136898002100166x.

Putri W (2019). Faktor Ibu terhadap Keja-dian Bayi Berat Lahir Rendah. Higea J of Public Health Res Development. 3(1): 55–62. doi: 10.15294 /higeia/v3i1/28692.

Sun CF, Liu H, Hao YH, Hu HT, Zhou ZY, Zou KX, Liu XM, et al. (2021). Association between gestational anemia in different trimesters and neonatal outcomes: a retrospective longitudinal cohort study. World J of Pediatr. 17(2): 197–204. doi: 10.1007/s1-251-9021-00411-6.

UNICEF (2019). Low Birth Weight. [Internet]. Available at: https://data.unicef.org/topic/nutrition/low-birth-weight/. Retrieved in February 7, 2022.

WHO (2014). WHA Global Nutrition Tar-gets 2025: Low Birth Weight Policy Brief. World Health Organization.

Zerfu TA, Umeta M, Baye K (2016). Dietary diversity during pregnancy is associated with reduced risk of maternal anemia, preterm delivery, and low birth weight in a prospective cohort study in rural Ethiopia. Am J of Clin Nutr. 103(6): 1482–1488. doi: 10.3945/ajcn.115.116798.

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Published
2022-04-16

Issue
Vol. 7 No. 2 (2022)

Section
flow-chart-line Articles

How to Cite
Tursina, E., & Adhimukti, F. (2022). The Effect of Maternal Anemia on Low Birth Weight: Meta Analysis. Journal of Epidemiology and Public Health, 7(2), 175–186. https://doi.org/10.26911/jepublichealth.2022.07.02.03