Meta-Analysis: The Effect of Neuropatic Complications and Depression Commorbidity on the Quality of Life of Patients with Type 2 Diabetes


  • Rofana Aghniya Masters Program in Public Health, Universitas Sebelas Maret
  • Bhisma Murti Masters Program in Public Health, Universitas Sebelas Maret
  • Didik Gunawan Tamtomo Faculty of Medicine, Universitas Sebelas Maret


Background: Diabetes mellitus is a metabolic disease that results from insulin insufficiency and often causes complications. DM patients are prone to depression. Depression is one aspect that affects the quality of life. Measuring the quality of life in DM patients is done as a measure of the success of the intervention. This study aims to estimate the influence of neuro


Adriaanse MC, Drewes HW, Van Der Heide I, Struijs JN, Baan C (2016). The impact of comorbid chronic conditions on quality of life in type 2 diabetes patients. Qual Life Res, 25: 175

Anderson RJ, Freedland KE, Clouse RE, Lustman PJ (2001). The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care, 24(6): 1069

Anulus A, Murti B, Prasetya H (2019). Risk Factors of HIV among Male Military Personnels: A Meta Analysis. J Health Promot and Behav, 4(3): 178

Benbow SJ, Wallymahmed ME, Macfarlane IA (1998). Diabetic peripheral neuro-pathy and quality of life. QJM, 91(11), 733

Chew BH, Mohd-Sidik S, Shariff-Ghazali S (2015). Negative effects of diabetes-related distress on health related quality of life: An evaluation among the adult patients with type 2 diabetes mellitus in three primary healthcare clinics in Malaysia. Health Qual. Life Outcomes, 13(1).

Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M (2011). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2

Danhauer SC, Brenes GA, Levine BJ, Young L, Tindle HA, Addington EL, Wallace RB, Naughton MJ, et al. (2019). Variability in sleep disturbance, physical activity and quality of life by level of depressive symptoms in women with Type 2 diabetes. Diabetic Medicine, 36(9), 1149

Derakhshanpour F, Vakili MA, Farsinia M, Mirkarimi K (2015). Depression and quality of life in patients with type 2 diabetes. Iran Red Crescent Med J. 17(5): e27676.

Egede LE, Grubaugh AL, Ellis C (2010). The effect of major depression on pre-ventive care and quality of life among adults with diabetes. Gen Hosp. Psychiatry, 32(6): 563

Gerontoukou EI, Michaelidoy S, Rekleiti M, Saridi M, Souliotis K (2015). Investigation of anxiety and depression in patients with chronic diseases. Health Psychol, 3(2).

Grandy S, Fox KM (2008). EQ-5D visual analog scale and utility index values in individuals with diabetes and at risk for diabetes: Findings from the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD). Health Qual. Life Outcomes, 6: 18.

Habtewold TD, Alemu SM, Haile YG (2016). Sociodemographic, clinical, and psychosocial factors associated with depression among type 2 diabetic outpatients in Black Lion General Specialized Hospital, Addis Ababa, Ethiopia: A cross-sectional study. BMC Psychiatry, 16(1): 1

Happich M, Breitscheidel L, Meisinger C, Ulbig M, Falkenstein P, Benter U, Watkins J (2007). Cross-sectional analysis of adult diabetes type 1 and type 2 patients with diabetic micro-vascular complications from a German retrospective observational study. Curr Med Res Opin. 23(6): 1367

Happich M, John J, Stamenitis S, Clouth J, Polnau D (2008). The quality of life and economic burden of neuropathy in diabetic patients in Germany in 2002 Results from the diabetic microvascular complications (DIMICO) study. Diabetes Res. Clin. Pract. 81(2): 223

Hutter N, Scheidt-Nave C, Baumeister H (2009). Health care utilisation and quality of life in individuals with diabetes and comorbid mental disorders. Gen. Hosp. Psychiatry. 31(1), 33

Iglay K, Hannachi H, Howie PJ, Xu J, Li X, Engel SS, Moore LM, Rajpathak S (2016). Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus. Curr Med Res Opin. 32(7): 1243

Landman GWD, Van Hateren KJJ, Kleef-stra N, Groenier KH, Gans ROB, Bilo HJG (2010). Health-related quality of life and mortality in a general and elderly population of patients with type 2 diabetes (ZODIAC18). Diabetes Care, 33(11): 2378

Lyrakos GN, Papazafiropoulou AK, Batistaki C, Xatziagelaki E, Damigos D, Tinas C, Mpakomitrou F, Bousboulas S, Spinaris V (2013). 1412

Murti B (2018). Prinsip dan Metode Riset Epidemiologi (Edisi V). Program Pascasarjana, Universitas Sebelas Maret. Surakarta: Bintang Fajar Offset.

Nouwen A, Winkley K, Twisk J, Lloyd CE, Peyrot M, Ismail K, Pouwer F (2010). Type 2 diabetes mellitus as a risk factor for the onset of depression: A systematic review and meta-analysis. Diabetologia, 53(12), 2480

Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Maka-roff LE (2017). IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabe-tes Res Clin Pract. 128: 40

Papadopoulos AA, Kontodimopoulos N, Frydas A, Ikonomakis E, Niakas D (2007). Predictors of health related quality of life in type II diabetic pati-ents in Greece. BMC Public Health, 7(1): 1

Papelbaum M, Lemos HM, Duchesne M, Kupfer R, Moreira RO, Coutinho WF (2010). The association between quality of life, depressive symptoms and glycemic control in a group of type 2 diabetes patients. Diabetes Res. Clin. Pract. 89(3): 227

Park M, Katon WJ, Wolf FM (2013). Depression and risk of mortality in individuals with diabetes: A meta-analysis and systematic review. Gen. Hosp. Psychiatry. 35(3): 217

Penckofer S, Quinn L, Byrn M, Ferrans C, Miller M, Strange P (2012). Does glycemic variability impact mood and quality of life? Diabetes Technol. Ther. 14(4): 303

Schram M, Baan C, Pouwer F (2009). Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium. Curr Diabetes Rev. 5(2): 112-9.

Smith BH, Torrance N (2012). Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep. 16(3): 191

Solli O, Stavem K, Kristiansen IS (2010). Health-related quality of life in diabetes: The associations of complications with EQ-5D scores. Health Qual. Life Outcomes. 8: 18.

Sterne JAC, Sutton AJ, Ioannidis JPA, Terrin N, Jones DR, Lau J, Carpenter J, R


Van Acker K, Bouhassira D, De Bacquer D, Weiss S, Matthys K, Raemen H, Mathieu C, Colin IM (2009). Preva-lence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics. Diabetes and Metabolism. 35(3): 206

Venkataraman K, Wee HL, Leow MKS, Tai ES, Lee J, Lim SC, Tavintharan S, Wong TY, Ma S, Heng D, Thumboo J (2013). Associations between compli-cations and health-related quality of life in individuals with diabetes. Clin Endocrinol (Oxf). 78(6): 865-73.

Wexler DJ, Grant RW, Wittenberg E, Bosch JL, Cagliero E, Delahanty L, Blais MA, Meigs JB (2006). Correlates of health-related quality of life in type 2 diabetes. Diabetologia, 49(7): 1489

Zhou B, Lu Y, Hajifathalian K, Bentham J, Di Cesare M, Danaei G, Bixby H, Cowan M, et al. (2016). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 387(10027): 1513




How to Cite

Aghniya, R., Murti, B., & Tamtomo, D. G. (2020). Meta-Analysis: The Effect of Neuropatic Complications and Depression Commorbidity on the Quality of Life of Patients with Type 2 Diabetes. Journal of Epidemiology and Public Health, 5(3), 359–371. Retrieved from




Most read articles by the same author(s)

> >>