Complication on Premature Rupture of Membrane in Intrapartum Mother Infected with COVID-19: Meta-Analysis
DOI:
https://doi.org/10.26911/jepublichealth.2022.07.04.01Abstract
Background: Pregnant women and fetuses are populations that are at high risk of being infected with the virus. COVID-19 in pregnant women is considered a risk factor for causing complications in pregnancy such as premature rupture of membranes. This study aims to analyze complications of premature rupture of membranes in mothers infected with COVID-19.
Subjects and Method: This was a systematic review and meta-analysis. Article searches were conducted using electronic databases such as Google Scholar, PubMed and Science Direct. The articles used are articles published from 2020-2022. Keywords to search for articles were: “COVID-19” OR “2019-nCoV” OR “novel coronavirus” OR “SARS-CoV-2” OR “coronavirus 2” AND “premature rupture of membrane” OR “prelabour rupture of membrane” AND “pregnancy.” The inclusion criteria used were full text articles in English with a cohort study design, multivariate analysis with Adjusted Odds Ratios (aOR), research subjects were pregnant women, intervention was COVID-19 infection, comparison was not infected with COVID-19 , the outcome of the study was premature rupture of membranes.The results of the search for articles were included in the PRISMA diagram and analyzed using the Review Manager 5.3 application.
Results: A total of 9 cohort study articles from the United States, Bangladesh, China, India, Mexico, Romania, and Spain were selected for systematic review and meta-analysis. The results showed that pregnant women infected with COVID-19 had a risk of complications of premature rupture of membranes as much as 2.26 times compared to pregnant women who were not infected with COVID-19 and the results were statistically significant (aOR = 2.26; 95% CI = 1.33 to 3.82; p = 0.002).
Conclusion: Pregnant women infected with COVID-19 increase the risk of premature rupture of membranes.
Keywords: COVID-19, pregnancy, premature rupture of membranes, meta-analysis
Correspondence:
Hepti Widia Ningsih. Masters Program in Public Health Universitas Sebelas Maret, Jl. Ir, Sutami 36A, Surakarta 51726, Central Java. Email: heptiwidian@gmail.com. Mobile +6285729442615.
References
Akhtar H, Patel C, Abuelgasim E, Harky A. (2020). COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review. Gynecol Obstet Invest. 85(4): 295–306. doi: 10.1159/000509290.
Alexander R, Rahimi A, Mukhtar ZD, Chandra R, Nasution SA (2021). Hubungan antara ketuban pecah dini dengan nilai Apgar pada kehamilan aterm (Relationship between premature rupture of membranes and Apgar value in term pregnancy). J. Prima Medika Sains. 3(1): 23–28. doi: 10.34012/jpms.v3i1.1775.
Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, Thangaratinam S (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: Living systematic review and meta-analysis. The BMJ. 370-375. doi: 10.1136/ bmj.m3320.
Amorita NA, Syahriarti I (2021). Karakte-ristik ibu hamil dengan COVID-19 dan luaran persalinannya di Rumah Sakit Kasih Ibu Surakarta (Characteristics of pregnant women with COVID-19 and delivery outcomes at Kasih Ibu Hospital Surakarta). J. Kesehatan Reproduksi. 8(1): 31. doi: 10.22146/jkr.63936.
Antoun L, Taweel NEl, Ahmed I, Patni S, Honest H (2020). Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. European J.Obstet Gynecol. 252(2):559-562. doi: 10.1016/j.ejogrb.2020.07.008.
Budiarti A, Dewi GPI, Hastuti P, Azri MZ (2021). Perilaku Pencegahan Covid-19 Pada Ibu Hamil (Covid-19 Prevention Behavior in Pregnant Women). J. Ilmu Keperawatan Maternitas. 4(2): 47-57. doi: 10.32 584/jikm.v4i2.1234.
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Zhang Y (2020). Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet. 395(10226): 809–815. doi: 10.1016/ S01406736-(20)30360-3.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Zhang L (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 395 (10223): 507–513. doi: 10.1016/S01406736(20)30211-7.
Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, Choolani M, Mattar C, SL (2020). Special Report and pregnancy. J.Obstet Gynecol. 222(6): 521–531. doi: 10.1016/j.ajog. 2020.04.013.
Du M, Yang J, Han N, Liu M, Liu J (2021). Association between the COVID-19 pandemic and the risk for adverse pregnancy outcomes: A cohort study. BMJ Open. 11(2). doi: 10.1136/bmj open2020047900.
Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, Sabbour M, et al. (2020). A systematic scoping review of COVID-19 During Pregnancy and Childbirth. International J. Gynaecol Obstet. 150(1): 47–52. doi: 10.1002/ ijgo.13182.
Huleihel M, Golan H, Hallak M (2004). Intrauterine infection/inflammation during pregnancy and offspring brain damages: Possible Mechanisms Involved. Reprod. Biol. Endocrinol. 2:17-27. doi: 10.1186/1477-7827-2-17.
Kasuga Y, Tanaka M, Ochiai D (2020). Preterm delivery and hypertensive disorder of pregnancy were reduced during the COVID-19 pandemic: A single hospital-based study. J. Obstet Gynaecol. 46(12): 2703–2704. doi: 10.1111/jog.14518.
Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, O'Brien P, et al. (2020). Characteristics and outcomes of pregnant women admitted to hospital with confirmed sars-cov-2 infection in UK: National Population Based Cohort Study. BMJ (Clinical Research Ed. 369: m2107. doi: 10.1136/bmj. m2107.
Legawati, Riyanti (2018). Determinan kejadian ketuban pecah dini (kpd) di ruang Cempaka RSUD DR Doris Sylvanus Palangkaraya (Determinants of the incidence of premature rupture of membranes (KPD) in the Cempaka Room, DR Doris Sylvanus Hospital, Palangkaraya). J. Surya Medika. 1(2): 30–42. doi: 10.16143/j.cnki.10019928.20 18.01.002.
López Y, Pintado-Recarte P, Cueto-Her-nández I, Hernández-Martín C, Payá-Martínez MP, Muñóz-Chápuli MDM, De León-Luis JA (2021). Review the profile of the obstetric patients with sars-cov-2 infection according to country of origin of the publication: A systematic review of the literature. J.Clinical Med. 10(2): 1–19. doi: 10.3390/ jcm10020360.
Mira M, Rizkia M (2020). Hubungan pengetahuan dengan perilaku ibu hamil dalam menjalani kehamilan selama masa pandemi COVID-19 (Relationship between knowledge and behavior of pregnant women in undergoing pregnancy during the COVID-19 Pandemic). J. Keperawatan Malang. 5(2): 80-86. doi: 10.36916/jkm.v5i2.110.
Nawsherwan KS, Zeb F, Shoaib M, Nabi G, Ulhaq I, Xu K, Li H (2020). Selected micronutrients: An option to boost immunity against COVID-19 and prevent adverse pregnancy outcomes in pregnant women: A Narrative Review. Iranian J. Public Health. 49(11): 2032–2043. doi: 10.3390/ijerph.18020596.
Panjaitan IM, Tarigan AM (2018). Hu-bungan karakteristik ibu bersalin dengan ketuban pecah dini di Rumah Sakit Martha Friska (The Relationship between maternal characteristics in maternity with premature rupture of membranes at Martha Friska Hospital). J. Bidan Komunitas. 1(2): 67. doi: 10.33085/jbk.v1i2.3938.
Pérez C, Mota VI, Repetto HAC, Gallegos AS, Bosch RM, Ríos AM, Irles C (2021). Prevalence, clinical features, and outcomes of SARS-CoV-2 Infection in pregnant women with or without mild/moderate symptoms: Results From Universal Screening In A Tertiary Care Center In Mexico City, Mexico. Plos One. 16(4): 1–19. doi: 10.1371/journal.pone.0249584.
Pradana TA, Surya IGNHW (2020). Karakteristik ibu bersalin dengan ketuban pecah dini (aterm & preterm) di Rumah Sakit Umum Pusat Sanglah Denpasar Periode Juli 2015-Juni 2016 (Characteristics of Mothers in Labor with Premature Rupture of Membranes (Aterm and Preterm) at Sanglah Central General Hospital Denpasar Period July 2015-June 2016). J. Medika Udayana. 9(1): 92–97.
Purwaningtyas ML, Prameswari GN (2017). Faktor kejadian anemia pada ibu hamil (Factors for the Incidence of Anemia in Pregnant Women). Higeia J. Public Health Research and Development. 1(3): 84–94.
Schwartz DA, Graham AL (2020). Potential maternal and infant outcomes from coronavirus 2019-NCOV (SARS-CoV-2) infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections. Viruses. 12(2): 1–16. doi: 10.3390/v12020194.
Wang C, Horby PW, Hayden FG, Gao GF (2020). A novel coronavirus outbreak of global health concern. The Lancet. 395(10223): 470–473. doi: 10.1016/ S01406736(20)30185-9.
Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, Li LJ (2020). Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retro spective case series. The BMJ. 368 (1): 1–7. doi: 10.1136/bmj. m606.
Yu N, Li W, Kang Q (2020). Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A Retrospective, Single-Centre, Descriptive Study. Lancet Infect Dis. 20(5):559– 564. doi: 10.1016/S1473-3099(20)30176-6.
Zaigham M, Andersson O (2020). Maternal and perinatal outcomes with COVID‐19: A systematic review of 108 pregnancies. Acta Obstet Gynecol of Scand. 99: 823–829.
