The Effect of Iron Deficiency Anemia on the Child Death Related to HIV/AIDS Infection: Meta-Analysis

Dyah Ambarwati, Yulia Lanti Retno Dewi, Bhisma Murti

Abstract

Background: A quarter of the world's popula­tion suffers from iron deficiency anemia with various causes. Anemia has an impact on a child's quality of life, even if it is of mild or moderate severity. This study aims to analyze the effect of hemoglobin levels on the mortality of children infected with HIV/AIDS using a meta-analysis.

Subjects and Method: This was a systematic review and meta-analysis. Article searches were conducted using electronic databases, namely Google Scholar and PubMed. Article sub­mission time is 1 month. Article search is done by several methods, namely boolean operators, handsearching, and keywords and MesH. The articles included in this study are articles that have a cohort study design. The systematics of article collection was carried out using the PRISMA-P flow chart. All articles were ana­lyzed using the Review Manager 5.3.

Results: Hemoglobin < 10 g/dl (aHR= 2.80; 95% CI=2.02 to 3.89; p<0.001), hemoglobin <9 g/dl (aHR= 1.82; 95% CI=1.31 to 2.51; p<0.001), and hemoglobin <8 g/dl (aHR= 1.77; 95% CI=1.43 to 2.20; p<0.001) has an effect on mortality of children infected with HIV/AIDS.

Conclusion: Low hemoglobin levels increase the risk of death in children infected with HIV/AIDS.

Keywords: hemoglobin, anemia, iron, child death

Correspondence: Dyah Ambarwati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ambarwati.dyah27@gmail.com. Mobile: +6287735486570

Journal of Epidemiology and Public Health (2021), 06(02): 158-169 

https://doi.org/10.26911/jepublichealth.2021.06.02.03

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References

Alebel A, Engeda EH, Kelkay MM, Petrucka P, Kibret GD, Wagnew F, Eshetie S (2020). Mortality rate among HIV-positive children on ART in Northwest Ethiopia: A historical cohort study. BMC Public Health, 20(1), 1–11. https://doi.org/10.1186/s12889-020-09418-6


Allali S, Brousse V, Sacri A, Chalumeau M, Montalembert Mde (2017). Expert Review of Hematology Anemia in children: prevalence, causes, diagnostic work up, and longterm consequences. Expert Review of Hematology, 10(11), 1023–1028. https://doi.org/10.1080/17474086.2017.1354696


Anaky MF, Duvignac J, Wemin L, Koua-koussui A, Karcher S, Touré S, Leroy V. (2009). Scaling up antiretroviral therapy for HIV-infected children in côte d’ivoire: Determinants of survival and loss to programme. Bulletin of the World Health Organization,88(7): 490–500. https://doi.org/10.2471/BLT.09.068015.


Auld AF, Tuho MZ, Ekra KA, Shiraishi RW, Mohamed F, Kouakou JS, Ellerbrock TV (2014). Temporal trends in mortality and loss to follow-up among children enrolled in côte d’ivoire’s national antiretroviral therapy pro-gram. Pediatric Infect Dis J, 33(11), 1134–1140. https://doi.org/10.1097/INF.0000000000000457.


Banna T, Manoppo IA (2019). Kualitas hidup orang dengan HIV dan AIDS (ODHA) ditinjau dari kualitas hidup orang dengan HIV dan AIDS (ODHA) ditinjau dari kepatuhan minum obat antiretroviral (ARV) (Quality of life of people living with HIV and AIDS (PLWHA) in terms of adherence to taking antiretroviral drugs (ARVs)). Wellness And Healthy Magazine, 1(February), 1–6.


Beletew B, Mengesha A, Ahmed M, Fitwi A, Wudu M (2020). Determinants of anemia among HIV-Positive Children on highly active antiretroviral therapy attending hospitals of North Wollo Zone, Amhara Region, Ethiopia, 2019: A case-control study. Hindawi Anemia, 1–10.


Duggal S, Chugh TDas, Duggal AK. (2012). HIV and malnutrition: Effects on immune system. Clin Develop Immunology, 2012. https://doi.org/10.1155/2012/784740


Gebremedhin A, Gebremariam S, Haile F, Weldearegawi B, Decotelli C. (2013). Predictors of mortality among HIV infected children on antiretroviral therapy in Mekelle Hospital, Northern Ethiopia: A retrospective cohort study. BMC Public Health, 13(1). https://doi.org/10.1186/1471-2458-13-1047


Hemsley S. (2019). Malnutrition is a world health crisis, says WHO expert (Dr. Francesco Branca). Retrieved March 12, 2021, from https://www.global-cause.co.uk/world-food-day/malnu-trition-is-a-world-health-crisis-says-who-expert/


Janssen N, Ndirangu J, Newell ML, Bland RM (2009). Successful paediatric HIV treatment in rural primary care in Africa. Arch Dis Childhood. 95(6): 414–421. https://doi.org/10.1136/adc.2009.169367


Jerath SG, Singh A, Jerath N, Gupta S & Racine EF. (2017). Undernutrition and severe acute malnutrition in children. The BMJ, 1–6.


Kedir AA, Desta A, Fesseha G. (2014). Factors affecting survival of HIV positive children taking antiretroviral therapy at Adama referral hospital and medical college, Ethiopia. Journal of AIDS and Clinical Research, 5(3). https://doi.org/10.4172/2155-6113.-1000289


Koye DN, Ayele TA, Zeleke BM (2012). Predictors of mortality among children on Antiretroviral Therapy at a referral hospital, Northwest Ethiopia: A retrospective follow up study. BMC Pediatrics, 12. https://doi.org/10.-1186/1471-2431-12-161


Moore CB, Mbewe MM, Cantrell RA, Chin-tu N, Stringer EM, Chi BH, Stringer JSA (2007). Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia. J Am Med Assoc. 298(16): 1888–1899.https://doi.org/10.1001-/jama.298.16.1888.


Mulaw GF, Yesuf FA, Abebe HT (2020). Magnitude of anemia and associated factors among HIV-infected children receiving antiretroviral therapy in Pastoral community, Ethiopia: A retrospective cross-sectional study. Advances in Hematology, 2020, 9–12. https://doi.org/10.1155/2020/9643901.


Munyagwa M, A Mworozi E, Ndeezi G, Mulumba Y, Ssali F (2020). Anaemia in HIV-Infected Children in A National Referral Hospital in Uganda: Prevalence and Associated Factors. Acta Scientific Med Sci. 4(3): 01–07. https://doi.org/10.31080/asms.2020.04.0556.


Mutanga JN, Mutembo S, Ezeamama AE, Song X, Fubisha RC, Mutesu-Kapembwa K, Whalen CC (2019). Longterm survival outcomes of HIV infected children receiving antiretroviral therapy: An observational study from Zambia (2003-2015). BMC Public Health, 19(1):1–12. https://doi.org/10.1186/s12889-019-6444-7.


Nasution SD (2015). Malnutrisi dan anemia pada penderita tuberkulosis paru (Malnutrition and anemia in patients with pulmonary tuberculosis). Majority, 4(8): 29–36.


Nath CL, Goday P (2019). Malnutrition in Children With Chronic Disease. Nutrition in Clinical Practice, 34(3), 349–358. https://doi.org/10.1002/ncp.10274


Nugent J, Edmonds A, Lusiama J, Thompson D, Behets F (2014). Predicting mortality in HIV-infected children initiating highly active antiretroviral therapy in a resource deprived setting. Pediatric Infect Dis J. 33(11), 1148–1155. http://doi.org/10.1097/INF.0000000000000454.


Oumer A, Kubsa ME, Mekonnen BA. (2019). Malnutrition as predictor of survival from antiretroviral treatment among children living with HIV/AIDS in Southwest Ethiopia: Survival analysis. BMC Pediatrics, 19(1). https://doi.org/10.1186/s1288-7-019-1823-x.


Rajasekaran S, Jeyaseelan L, Ravichandran N, Gomathi C, Thara F, Chandrasekar C (2008). Efficacy of antiretroviral therapy program in children in India: prognostic factors and survival analysis. Acad Oup Com. https://academic.oup.com/tropej/article-abs-tract/55/4/225/1672421.


Roganovic J, Starinac K (2018). Iron deficiency anemia in children. Curr Topics Amenia. 1–27. https://doi.org/10.5772/intechopen.69774.


Salvadori N, Ngo-Giang-Huong N, Ducle-rcq C, Kanjanavanit S, Ngampiyaskul C, Techakunakorn P, Jourdain G (2017). Incidence of tuberculosis and associated mortality in a cohort of human immunodeficiency virus-infected children initiating antiretroviraltherapy. J Pediatric Infect Dis Soc. 6(2): 161–167. https://doi.org/10.1093/jpids/piw090.


Sashindran Vk, Thakur R (2020). Malnu-trition in HIV/AIDS; Aetiopathogenesis. Intech, (tourism), 13. Retrieved from https://www.intechopen.com/books/advanced-biometric-technologies/liveness-detection-in-biometrics


Shet A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel NM, Kurpad AV. (2009). Anemia and growth failure among HIV-infected children in India: a retrospective analysis. BMC Pediatrics, 9: 1–9. https://doi.org/10.1186/1471-2431-9-37.


Sidamo NB, Debere MK, Enderis B, Misker AD (2017). Incidence and predictors of mortality among children on antiretroviral therapy in public health facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective cohort study. Clin Mother

Child Health. 14(3). https://doi.org/10.4172/2090-7214.1000267.


Sutcliffe CG, van Dijk JH, Munsanje B, Hamangaba F, Siniwymaanzi P, Thuma PE, Moss WJ (2011). Risk factors for pretreatment mortality among HIV-infected children in rural Zambia: A cohort study. PLoS ONE, 6(12). https://doi.org/10.1371/jour-nal.pone.0029294.


Wagnew F, Eshetie S, Alebel A, Tesema C, Kibret GD, Gebrie A, Abajobir AA (2019). Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 1–9.


Wamalwa DC, Obimbo EM, Farquhar C, Richardson BA, Mbori-Ngacha DA, Inwani I, John-Stewart G (2010). Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: A prospective cohort. BMC Pediatrics, 10: 4–11. https://doi.org/10.1186/1471-2431-10-33.


WHO (2006). Antiretrovirals for HIV: a compilation of facts and product information.


Zhao Y, Li C, Sun X, Mu W, McGoogan JM, He Y, Zhang F (2013). Mortality and treatment outcomes of China’s national pediatric antiretroviral therapy program. Clinical Infectious Diseases, 56(5): 735–744. https://doi.org/10.1093/cid/cis941




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