Meta Analysis: Effect of Mammography Screening on Breast Cancer Mortality

Bening Rahimi Titisari, Vitri Widyaningsih, Bhisma Murti


Background: Breast cancer is the most common cancer experienced by women in developing and developed countries. One of the early detection of breast cancer is mammo­graphy. This study aims to analyze the effect of screening mammography on breast cancer mortality by using a meta-analysis study.

Subjects and Method: This was a systematic review and meta-analysis conducted using PRISMA flow diagrams. Search articles through journal databases including: Google Scholar, PubMed, and BMJ by selecting articles published in 2005-2020. The keywords used are “Mammography” AND “Mortality” AND “Breast Cancer”. The inclusion criteria were full text articles with an observational study design, articles in English, multivariate analysis with adjusted Hazard Ratio. Eligible articles were analyzed using the Revman5.3 app.

Results: A meta-analysis of 11 cohort studies showed that screening mammography was 0.65 times lower in breast cancer mortality com­pared with women who were not screened for mammography (aHR= 0.65; 95% CI= 0.54 to 0.79; p=0.0001).).

Conclusion: Mammography screening reduces breast cancer mortality.

Keywords: Mammography Screening, Breast Cancer, Meta-analysis

Correspondence: Bening Rahimi Titisari. Masters Program in Public Health, Universitas Sebelas Maret. Jl.Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 082­194287848

Journal of Epidemiology and Public Health (2021), 06(02): 148-157

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