The Effect of Non-Compliance with Medication on Multidrug Resistant of Tuberculosis

Widya Kurnianingsih, Didik Gunawan Tamtomo, Bhisma Murti


Background: Multidrug Resistant Tubercu­losis (MDR-TB) is the biggest problem in the prevention and eradication of TB in the world. MDR TB exists in 27 countries where there are at least 6,800 MDR TB cases every year and 12% of new TB cases registered are MDR TB. MDR-TB is a disease caused by resistant Myco­bacterium tuberculosis. This study aims to exa­mine the effect of non-compliance with taking medication on the incidence of multidrug resistant tuberculosis (MDR TB).

Subjects and Method: The problems of this study with PICO are as follows: Population= TB patients, Intervention = Non-compliance with taking medication. Comparison= Adherence to taking medication, and Outcome= Incidence of Multidrug Resistant Tuberculosis. Meta- analy­sis was carried out by systematically reviewing articles from Google Scholar, Pubmed and Springer Link. The articles used in this research are articles that have been published from 2010-2019. The keywords to look for articles are as follows: "Risk Factor MDR TB" OR "Pre­vious Treatment" AND "Multidrug resistant tuberculosis". The inclusion criteria used were full paper, used English, case control study design and the results reported were adjusted odds ratio. Articles were collected using the PRISMA diagram and analyzed using the Review Manager 5.3 application with a fixed effect model.

Results: A total of nine articles reviewed in this study came from Bangladesh, Malaysia, Pakistan and Ethiopia. This resulted in a study showing that the effect of incomplete treatment increased the risk of multidrug resistant tuber­culosis (aOR= 10.04; 95% CI= 8.90 to 11.32; p <0.001).

Conclusion: The effect of incomplete treat­ment increases the risk of multidrug resistant tuberculosis in Taiwan, Bangladesh, Malaysia and Ethiopia.

Keywords: Effect of incomplete treatment, Multidrug resistant tuberculosis (MDR TB)

Correspondence: Widya Kurnianingsih. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57125, Central Java. Email: Mo­bile: 081556837033.

Journal of Epidemiology and Public Health (2020), 05(04): 393-401

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