Effects of Blood Transfusion on the Risk of Hepatitis C Infection in Hemodialysis Patients: A Meta-Analysis

Yuli Astuti, Yulia Lanti Retno Dewi, Bhisma Murti


Background: It is estimated that 2% of the world's population (about 123 million people) was infected with hepatitis C. Blood transfusion is one of the therapies, but this therapy is at risk of being a transmission me­dium for hepatitis B infection. Hemo­dia­ly­sis patients are in the group at risk of having hepatitis C infection. Patients with a history of blood transfusions in this group increase the incidence of hepatitis C infec­tion. This study aimed to determine the estimated effect of blood transfusions on hepatitis C infec­tion in hemodialysis pa­tients with a meta-analysis.

Subjects and Method: Meta-analysis was con­duc­ted by searching for articles from databases such as Google Scholar, Pub­Med, Springer Link, and Research Gate. The keywords were "blood tran­s­fu­sion" OR "risk factor" AND "hepatitis C in­fec­tion" OR "TTI" OR "HBV" AND "patient hemo­dialysis" OR "Patient renal failure". The inclusion criteria were full-text articles, from 2000-2020, with a cross-sectional stu­dy design. The articles were analyzed using RevMan 5.3.

Results: There were 9 articles analyzed. The results showed that blood transfusions in­creased the incidence of hepatitis C infec­tion in hemo­dia­ly­sis patients (aOR= 1.55; 95% CI= 1.19 to 2.03; p= 0.001) and I2= 90%. Based on the meta-ana­lysis result, there was no publication bias.

Conclusion: Blood transfusion affects he­mo­­dia­lys­is patients with hepatitis C in­fec­tion.

Keywords: blood transfusion, hepatitis C infec­tion, hemodialysis patients

Correspondence: Yuli Astuti. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Sura­kar­ta 57126, Central Java. Email: ­yuli­as­tu­ti­12­2­4­@gmail.com. Mobile: 0838­2­1­875621

Journal of Epidemiology and Public Health (2020), 05(03): 339-347


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